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IL-34 affects fibroblast-like synoviocyte proliferation, apoptosis and function by regulating IL-17

12 Aug 2021

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by proliferation and insufficient apoptosis of fibroblast-like synoviocytes (FLSs).The biology and functions of interleukin (IL)-34 are only beginning to be uncovered. We previously demonstrated IL-34 could upregulate the expression of IL-17 in RA patients. In this study, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide...

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PMID: 34385542
DOI: 10.1038/s41598-021-95839-1

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