Article
Clinical efficacy and safety of ruxolitinib in the management of myelofibrosis: A single institution experience in Taiwan.
Hematology (Amsterdam, Netherlands) - 1 Jan 2016
Chen Yi-Yang, Huang Cih-En, Lee Kuan-Der, Chen Chih-Cheng
Abstract excerpt
OBJECTIVE: Myelofibrosis (MF) is a pathologic entity of myeloproliferative neoplasm (MPN) characterized by bone marrow fibrosis, extramedullary hematopoiesis, splenomegaly, and constitutional symptoms that severely affect the quality of life accompanied with the risk of leukemia development. Conventional treatment is usually ineffective and has limited impact on prolongation of survival. Dysregulated Janus kinase...
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