Article
Myelofibrosis: an update on current pharmacotherapy and future directions.
Expert opinion on pharmacotherapy - 1 May 2013
Cervantes Francisco, Martinez-Trillos Alejandra
Abstract excerpt
INTRODUCTION: Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by symptoms mainly derived from anemia and splenomegaly and constitutional symptoms and associated with a median survival around 6 years. Allogeneic stem cell transplantation (allo-SCT) remains the only curative therapy of MF but is applicable to a minority of patients. Discovery of the JAK2 mutation has provided the basis for the...
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