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Article

Recent advances in the diagnosis and management of primary myelofibrosis.

The Korean journal of internal medicine - 1 Jul 2018

Takenaka Katsuto, Shimoda Kazuya, Akashi Koichi

Abstract excerpt

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) in which dysregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathways is the major pathogenic mechanism. Most patients with PMF carry a driver mutation in the JAK2, MPL (myeloproliferative leukemia), or CALR (calreticulin) genes. Mutations in epigenetic regulators and RNA splicing genes may...

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Source

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Identifiers

PMID: 29665657
DOI: 10.3904/kjim.2018.033
PMCID: PMC6030412

Genes

JAK2
CALR
MPL

Provenance

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