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Article

[Recent advances in the treatment of myelofibrosis].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2020

Takenaka Katsuto

Abstract excerpt

Primary myelofibrosis (PMF) is classified as a clonal myeloproliferative neoplasm (MPN) characterized by bone marrow fibrosis and subsequent extramedullary hematopoiesis that causes progressive anemia, symptomatic splenomegaly, and various constitutional symptoms and eventual transformation into acute leukemia. The main MPN pathophysiology is the constitutive activation of JAK2/STAT signaling. JAK2, MPL, and CALR...

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Identifiers

PMID: 33162516
DOI: 10.11406/rinketsu.61.1195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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