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Article

The association of DNA methyltransferase 1 gene polymorphisms with susceptibility to childhood acute lymphoblastic leukemia.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jul 2015

Luo Ying, Yu Luting, Yu Tingting, Jiang Feixia, Cai Xubing, Zhao Yilun, Pan Shiyang, Luo Chen

Abstract excerpt

BACKGROUND: It has been suggested that aberrant DNA methylation is a common epigenetic alteration in malignancies. Genetic variations in DNA methyltransferase 1 gene (DNMT1), which encodes the maintenance methyltransferase, have been demonstrated to be involved in cancer susceptibility. In the present study, we investigated whether genetic polymorphisms in DNMT1 could be associated with risk of childhood acute...

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Identifiers

PMID: 26211580
DOI: 10.1016/j.biopha.2015.05.001

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DNMT1

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