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Article

β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D.

PloS one - 1 Jan 2011

Trian Thomas, Burgess Janette K, Niimi Kyoko, Moir Lyn M, Ge Qi, Berger Patrick, Liggett Stephen B, Black Judith L, Oliver Brian G

Abstract excerpt

BACKGROUND AND OBJECTIVE: Asthma is associated with airway narrowing in response to bronchoconstricting stimuli and increased airway smooth muscle (ASM) mass. In addition, some studies have suggested impaired β-agonist induced ASM relaxation in asthmatics, but the mechanism is not known. OBJECTIVE: To characterize the potential defect in β-agonist induced cAMP in ASM derived from asthmatic in comparison to...

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Share to Adrenergic beta-2 Receptor Agonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic Nucleotide Phosphodiesterases, Type 3

Share to Cyclic Nucleotide Phosphodiesterases, Type 4

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Share to Muscle, Smooth

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Source

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Identifiers

PMID: 21611147
DOI: 10.1371/journal.pone.0020000
PMCID: PMC3096656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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