Article
Post-transcriptional gene silencing triggered by sense transgenes involves uncapped antisense RNA and differs from silencing intentionally triggered by antisense transgenes.
Nucleic acids research - 30 Sept 2015
Parent Jean-Sébastien, Jauvion Vincent, Bouché Nicolas, Béclin Christophe, Hachet Mélanie, Zytnicki Matthias, Vaucheret Hervé
Abstract excerpt
Although post-transcriptional gene silencing (PTGS) has been studied for more than a decade, there is still a gap in our understanding of how de novo silencing is initiated against genetic elements that are not supposed to produce double-stranded (ds)RNA. Given the pervasive transcription occurring throughout eukaryote genomes, we tested the hypothesis that unintended transcription could produce antisense (as)RNA...
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