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Article

A Novel Mutation of DAX-1 Associated with Secretory Azoospermia.

PloS one - 1 Jan 2015

Mou Lisha, Xie Nie, Yang Lihua, Liu Yuchen, Diao Ruiying, Cai Zhiming, Li Honggang, Gui Yaoting

Abstract excerpt

Secretory azoospermia is a severe form of male infertility caused by unknown factors. DAX-1 is predominantly expressed in mammalian reproductive tissues and plays an important role in spermatogenesis because Dax-1 knockout male mice show spermatogenesis defects. To examine whether DAX-1 is involved in the pathogenesis of secretory azoospermia in humans, we sequenced all of the exons of DAX-1 in 776 patients...

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Share to Azoospermia
Share to DAX-1 Orphan Nuclear Receptor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Source

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Identifiers

PMID: 26207377
DOI: 10.1371/journal.pone.0133997
PMCID: PMC4514677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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