Article
A single-nucleotide polymorphism of the DAZL gene promoter confers susceptibility to spermatogenic failure in the Taiwanese Han.
Human reproduction (Oxford, England) - 1 Sept 2012
Teng Yeng-Ni, Chang Yi-Ping, Tseng Joseph T, Kuo Po-Hsiu, Lee I-Wen, Lee Maw-Sheng, Kuo Pao-Lin
Abstract excerpt
BACKGROUND: Deleted in AZoospermia-like (DAZL) is an autosomal homologue of Y chromosome-linked DAZ gene located on chromosome 3p24. DAZL is only expressed in the gonads and is critical to germ cell development in different species. However, the regulation of DAZL has not been explored. METHODS: Reporter assays, electrophoretic mobility shift assays, supershift assays and bisulfate sequencing were used to...
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