Article
Asp3Gly polymorphism affects fatty acid-binding protein 3 intracellular stability and subcellular localization.
FEBS letters - 19 Aug 2015
Kusudo Tatsuya, Hashida Yasuhiko, Ando Fujiko, Shimokata Hiroshi, Yamashita Hitoshi
Abstract excerpt
Fatty acid-binding proteins (FABP) play a crucial role in intracellular fatty acid transportation and metabolism. In this study, we investigate the effects of the FABP3 Asp3Gly (D3G) polymorphism on protein structure and function. Although the mutation did not alter protein secondary structure or the ability to bind 1-anilinonaphthalene-8-sulfonic acid and palmitate, the intracellular stability of the D3G mutant...
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