Article
A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice.
Biology of reproduction - 1 Sept 2015
Kauffman Alexander S, Thackray Varykina G, Ryan Genevieve E, Tolson Kristen P, Glidewell-Kenney Christine A, Semaan Sheila J, Poling Matthew C, Iwata Nahoko, Breen Kellie M, Duleba Antoni J, Stener-Victorin Elisabet, Shimasaki Shunichi, Webster Nicholas J, Mellon Pamela L
Abstract excerpt
Polycystic ovary syndrome (PCOS) pathophysiology is poorly understood, due partly to lack of PCOS animal models fully recapitulating this complex disorder. Recently, a PCOS rat model using letrozole (LET), a nonsteroidal aromatase inhibitor, mimicked multiple PCOS phenotypes, including metabolic features absent in other models. Given the advantages of using genetic and transgenic mouse models, we investigated...
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