Article
Rodent models of polycystic ovary syndrome: phenotypic presentation, pathophysiology, and the effects of different interventions.
Seminars in reproductive medicine - 1 May 2014
Maliqueo Manuel, Benrick Anna, Stener-Victorin Elisabet
Abstract excerpt
This review focuses on rodent models exposed to sex steroids prepubertally and describes their phenotypes and pathophysiology with specific focus on the estradiol valerate-, dihydrotestosterone-, and letrozole-induced rat polycystic ovary syndrome (PCOS) models. Phenotypic presentations are compared among models as a function of the timing and dose of the exposure. Furthermore, the use of these models to study...
Topics
- Animals
- Disease Models, Animal
- Female
- Humans
- Phenotype
- Polycystic Ovary Syndrome
- Rats
