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Article

Influenza Virus Susceptibility of Wild-Derived CAST/EiJ Mice Results from Two Amino Acid Changes in the MX1 Restriction Factor.

Journal of virology - 1 Dec 2016

Nürnberger Cindy, Zimmermann Vanessa, Gerhardt Melanie, Staeheli Peter

Abstract excerpt

The interferon-regulated Mx1 gene of the A2G mouse strain confers a high degree of resistance against influenza A and Thogoto viruses. Most other laboratory inbred mouse strains carry truncated nonfunctional Mx1 alleles and, consequently, exhibit high virus susceptibility. Interestingly, CAST/EiJ mice, derived from wild Mus musculus castaneus, possess a seemingly intact Mx1 gene but are highly susceptible to...

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Identifiers

PMID: 27654285
DOI: 10.1128/JVI.01213-16
PMCID: PMC5110186

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CAST

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