Article
Logical-continuous modelling of post-translationally regulated bistability of curli fiber expression in Escherichia coli.
BMC systems biology - 23 Jul 2015
Yousef Kaveh Pouran, Streck Adam, Schütte Christof, Siebert Heike, Hengge Regine, von Kleist Max
Abstract excerpt
BACKGROUND: Bacteria have developed a repertoire of signalling mechanisms that enable adaptive responses to fluctuating environmental conditions. The formation of biofilm, for example, allows persisting in times of external stresses, e.g. induced by antibiotics or a lack of nutrients. Adhesive curli fibers, the major extracellular matrix components in Escherichia coli biofilms, exhibit heterogeneous expression in...
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