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Article

Bistability in a metabolic network underpins the de novo evolution of colony switching in Pseudomonas fluorescens.

PLoS biology - 1 Mar 2015

Gallie Jenna, Libby Eric, Bertels Frederic, Remigi Philippe, Jendresen Christian B, Ferguson Gayle C, Desprat Nicolas, Buffing Marieke F, Sauer Uwe, Beaumont Hubertus J E, Martinussen Jan, Kilstrup Mogens, Rainey Paul B

Abstract excerpt

Phenotype switching is commonly observed in nature. This prevalence has allowed the elucidation of a number of underlying molecular mechanisms. However, little is known about how phenotypic switches arise and function in their early evolutionary stages. The first opportunity to provide empirical insight was delivered by an experiment in which populations of the bacterium Pseudomonas fluorescens SBW25 evolved, de...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25763575
DOI: 10.1371/journal.pbio.1002109
PMCID: PMC4357382

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