Article
Analysis of KaiA-KaiC protein interactions in the cyano-bacterial circadian clock using hybrid structural methods.
The EMBO journal - 3 May 2006
Pattanayek Rekha, Williams Dewight R, Pattanayek Sabuj, Xu Yao, Mori Tetsuya, Johnson Carl H, Stewart Phoebe L, Egli Martin
Abstract excerpt
The cyanobacterial circadian clock can be reconstituted in vitro by mixing recombinant KaiA, KaiB and KaiC proteins with ATP, producing KaiC phosphorylation and dephosphorylation cycles that have a regular rhythm with a ca. 24-h period and are temperature-compensated. KaiA and KaiB are modulators...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Biological Clocks
- Circadian Rhythm
- Circadian Rhythm Signaling Peptides and Proteins
- Crystallography, X-Ray
- Microscopy, Electron
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Interaction Mapping
- Sequence Deletion