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Article

How fungal multidrug transporters mediate hyper resistance through DNA amplification and mutation.

Molecular microbiology - 1 Jul 2022

Banerjee Atanu, Rahman Hadiar, Prasad Rajendra, Golin John

Abstract excerpt

A significant portion of clinically observed antifungal resistance is mediated by ATP-binding cassette (ABC) and major facilitator superfamily (MFS) transport pumps that reside in the plasma membrane. We review the mechanisms responsible for this phenomenon. Hyper resistance is often brought about by several kinds of DNA amplification or by gain-of-function mutations in a variety of transcription factors. Both of...

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Identifiers

PMID: 35611562
DOI: 10.1111/mmi.14947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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