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Article

Immortalisation with hTERT Impacts on Sulphated Glycosaminoglycan Secretion and Immunophenotype in a Variable and Cell Specific Manner.

PloS one - 1 Jan 2015

Dale Tina P, de Castro Alice, Kuiper Nicola J, Parkinson E Kenneth, Forsyth Nicholas R

Abstract excerpt

BACKGROUND: Limited options for the treatment of cartilage damage have driven the development of tissue engineered or cell therapy alternatives reliant on ex vivo cell expansion. The study of chondrogenesis in primary cells is difficult due to progressive cellular aging and senescence. Immortalisation via the reintroduction of the catalytic component of telomerase, hTERT, could allow repeated, longitudinal...

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Source

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Identifiers

PMID: 26196672
DOI: 10.1371/journal.pone.0133745
PMCID: PMC4510558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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