Article
Immortalization of bone marrow-derived human mesenchymal stem cells by removable simian virus 40T antigen gene: analysis of the ability to support expansion of cord blood hematopoietic progenitor cells.
International journal of oncology - 1 Oct 2003
Nishioka Keisuke, Fujimori Yoshihiro, Hashimoto-Tamaoki Tomoko, Kai Shunro, Qiu Huiying, Kobayashi Naoya, Tanaka Noriaki, Westerman Karen A, Leboulch Philippe, Hara Hiroshi
Abstract excerpt
Human marrow-derived mesenchymal stem cells (MSC), which have the potential to differentiate into mesenchymal tissues, such as bone, cartilage, adipose and bone marrow stroma, were transduced with a retroviral vector carrying the simian virus 40 large T antigen, hygromycin-resistant gene and herpes simplex virus thymidine kinase gene, that can be excised by Cre/loxP site-specific recombination. This resulted in...
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