Article
Gamma-irradiated human amniotic membrane decellularised with sodium dodecyl sulfate is a more efficient substrate for the ex vivo expansion of limbal stem cells.
Acta biomaterialia - 1 Oct 2017
Figueiredo G S, Bojic S, Rooney P, Wilshaw S-P, Connon C J, Gouveia R M, Paterson C, Lepert G, Mudhar H S, Figueiredo F C, Lako M
Abstract excerpt
The gold standard substrate for the ex vivo expansion of human limbal stem cells (LSCs) remains the human amniotic membrane (HAM) but this is not a defined substrate and is subject to biological variability and the potential to transmit disease. To better define HAM and mitigate the risk of disease transmission, we sought to determine if decellularisation and/or γ-irradiation have an adverse effect on culture...
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