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Article

Identification of Androgen Receptor Splice Variants in the Pten Deficient Murine Prostate Cancer Model.

PloS one - 1 Jan 2015

Liang Mengmeng, Adisetiyo Helty, Li Xiuqing, Liu Xiuqing, Liu Ren, Gill Parkash, Roy-Burman Pradip, Jones Jeremy O, Mulholland David J

Abstract excerpt

Androgen receptor (AR) variants are associated with resistance to anti androgen therapy both in human prostate cancer cell lines and clinical samples. These observations support the hypothesis that AR isoform accumulation is a consequence of selective therapeutic pressure on the full length AR. The Pten deficient prostate cancer model proceeds with well-defined kinetics including progression to castration...

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Share to Cell Line, Tumor
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prostatic Neoplasms, Castration-Resistant

Share to PTEN Phosphohydrolase

Share to Receptors, Androgen

Share to RNA Splice Sites

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Source

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Identifiers

PMID: 26196517
DOI: 10.1371/journal.pone.0131232
PMCID: PMC4510390

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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