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Androgen Receptor Gene Rearrangements: New Perspectives on Prostate Cancer Progression

1 Mar 2013

Abstract excerpt

The androgen receptor (AR) is a master regulator transcription factor in normal and cancerous prostate cells. Canonical AR activation requires binding of androgen ligand to the AR ligand binding domain, translocation to the nucleus, and transcriptional activation of AR target genes. This regulatory axis is targeted for systemic therapy of advanced prostate cancer. However, a new paradigm for AR activation in...

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PMID: 23410127
DOI: 10.2174/1389450111314040005

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