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Article

Epidemiologic Correlates of Pyrazinamide-Resistant Mycobacterium tuberculosis in New York City.

Antimicrobial agents and chemotherapy - 1 Oct 2015

Verdugo Dawn, Fallows Dorothy, Ahuja Shama, Schluger Neil, Kreiswirth Barry, Mathema Barun

Abstract excerpt

Pyrazinamide (PZA) has important sterilizing activity in tuberculosis (TB) chemotherapy. We describe trends, risk factors, and molecular epidemiology associated with PZA-resistant (PZA(r)) Mycobacterium tuberculosis in New York City (NYC). From 2001 to 2008, all incident culture-positive TB cases reported by the NYC Department of Health and Mental Hygiene (DOHMH) were genotyped by IS6110-based restriction...

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Identifiers

PMID: 26195530
DOI: 10.1128/AAC.00764-15
PMCID: PMC4576106

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