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A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell Death

1 Jul 2015

Abstract excerpt

West Nile virus (WNV) causes an acute neurological infection attended by massive neuronal cell death. However, the mechanism(s) behind the virus-induced cell death is poorly understood. Using a library containing 77,406 sgRNAs targeting 20,121 genes, we performed a genome-wide screen followed by a second screen with a sub-library. Among the genes identified, seven genes, EMC2, EMC3, SEL1L, DERL2, UBE2G2, UBE2J1,...

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PMID: 26190106
DOI: 10.1016/j.celrep.2015.06.049

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