Article
The Evolutionary History of Common Genetic Variants Influencing Human Cortical Surface Area.
Cerebral cortex (New York, N.Y. : 1991) - 5 Mar 2021
Tilot Amanda K, Khramtsova Ekaterina A, Liang Dan, Grasby Katrina L, Jahanshad Neda, Painter Jodie, Colodro-Conde Lucía, Bralten Janita, Hibar Derrek P, Lind Penelope A, Liu Siyao, Brotman Sarah M, Thompson Paul M, Medland Sarah E, Macciardi Fabio, Stranger Barbara E, Davis Lea K, Fisher Simon E, Stein Jason L
Abstract excerpt
Structural brain changes along the lineage leading to modern Homo sapiens contributed to our distinctive cognitive and social abilities. However, the evolutionarily relevant molecular variants impacting key aspects of neuroanatomy are largely unknown. Here, we integrate evolutionary annotations of the genome at diverse timescales with common variant associations from large-scale neuroimaging genetic screens. We...
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