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Article

STAT3 polymorphism and Helicobacter pylori CagA strains with higher number of EPIYA-C segments independently increase the risk of gastric cancer.

BMC cancer - 19 Jul 2015

Rocha Gifone A, Rocha Andreia M C, Gomes Adriana D, Faria César Ll, Melo Fabrício F, Batista Sérgio A, Fernandes Viviane C, Almeida Nathálie B F, Teixeira Kádima N, Brito Kátia S, Queiroz Dulciene Maria Magalhães

Abstract excerpt

BACKGROUND: Because to date there is no available study on STAT3 polymorphism and gastric cancer in Western populations and taking into account that Helicobacter pylori CagA EPIYA-C segment deregulates SHP-2/ERK-JAK/STAT3 pathways, we evaluated whether the two variables are independently associated with gastric cancer. METHODS: We included 1048 subjects: H. pylori-positive patients with gastric carcinoma (n =...

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Source

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Identifiers

PMID: 26186918
DOI: 10.1186/s12885-015-1533-1
PMCID: PMC4506573

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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