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Article

ZNF555 protein binds to transcriptional activator site of 4qA allele and ANT1: potential implication in Facioscapulohumeral dystrophy.

Nucleic acids research - 30 Sept 2015

Kim Elena, Rich Jeremy, Karoutas Adam, Tarlykov Pavel, Cochet Emilie, Malysheva Daria, Mamchaoui Kamel, Ogryzko Vasily, Pirozhkova Iryna

Abstract excerpt

Facioscapulohumeral dystrophy (FSHD) is an epi/genetic satellite disease associated with at least two satellite sequences in 4q35: (i) D4Z4 macrosatellite and (ii) β-satellite repeats (BSR), a prevalent part of the 4qA allele. Most of the recent FSHD studies have been focused on a DUX4 transcript inside D4Z4 and its tandem contraction in FSHD patients. However, the D4Z4-contraction alone is not pathological,...

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Topics

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Share to Chromosomes, Human, Pair 4
Share to DNA, Satellite

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Microfilament Proteins

Share to Muscular Dystrophy, Facioscapulohumeral

Share to Myoblasts

Share to RNA-Binding Proteins

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 26184877
DOI: 10.1093/nar/gkv721
PMCID: PMC4787827

Genes

DUX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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