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Article

4q-D4Z4 chromatin architecture regulates the transcription of muscle atrophic genes in FSHD

2019-04-30

Abstract excerpt

Despite increasing insights in genome structure organization, the role of DNA repetitive elements, accounting for more than two thirds of the human genome, remains elusive. Facioscapulohumeral Dystrophy (FSHD) is associated with deletion of D4Z4 repeat array below 11 units at 4q35.2. It is known that the deletion alters chromatin structure in cis , leading to genes upregulation. Here we show a genome-wide role of...

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Literature Corpus work
5e1883b5-f5dd-5e74-a506-2b046a97ab2a
DOI
10.1101/623363
Open publication

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4q-D4Z4 chromatin architecture regulates the transcription of muscle atrophic genes in FSHDDOI 10.1101/623363
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