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Article

A Functional Role for 4qA/B in the Structural Rearrangement of the 4q35 Region and in the Regulation of FRG1 and ANT1 in Facioscapulohumeral Dystrophy

10 Oct 2008

Abstract excerpt

The number of D4Z4 repeats in the subtelomeric region of chromosome 4q is strongly reduced in patients with Facio-Scapulo-Humeral Dystrophy (FSHD). We performed chromosome conformation capture (3C) analysis to document the interactions taking place among different 4q35 markers. We found that the reduced number of D4Z4 repeats in FSHD myoblasts was associated with a global alteration of the three-dimensional...

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PMID: 18852887
DOI: 10.1371/journal.pone.0003389

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A Functional Role for 4qA/B in the Structural Rearrangement of the 4q35 Region and in the Regulation of FRG1 and ANT1 in Facioscapulohumeral DystrophyPMID 18852887Read ↗

Analysis of the 4q35 chromatin organization reveals distinct long-range interactions in patients affected with Facio-Scapulo-Humeral Dystrophy.Semantic proximity Read ↗

Analysis of the 4q35 chromatin organization reveals distinct long-range interactions in patients affected with Facio-Scapulo-Humeral DystrophySemantic proximity Read ↗

The D4Z4 Macrosatellite Repeat Acts as a CTCF and A-Type Lamins-Dependent Insulator in Facio-Scapulo-Humeral DystrophySemantic proximity Read ↗

4q-D4Z4 chromatin architecture regulates the transcription of muscle atrophic genes in FSHDSemantic proximity Read ↗

ZNF555 protein binds to transcriptional activator site of 4qA allele and ANT1: potential implication in Facioscapulohumeral dystrophy.Semantic proximity Read ↗

Identification of the first gene (FRG1) from the FSHD region on human chromosome 4q35.Semantic proximity Read ↗

Facioscapulohumeral Muscular Dystrophy: More Complex than it AppearsSemantic proximity Read ↗

Deciphering the complexity of the 4q and 10q subtelomeres by molecular combing in healthy individuals and patients with facioscapulohumeral dystrophySemantic proximity Read ↗

Specific sequence variations within the 4q35 region are associated with facioscapulohumeral muscular dystrophy.Semantic proximity Read ↗

High-resolution breakpoint junction mapping of proximally extended D4Z4 deletions in FSHD1 reveals evidence for a founder effect.Semantic proximity Read ↗

Contractions of D4Z4 on 4qB subtelomeres do not cause facioscapulohumeral muscular dystrophy.Semantic proximity Read ↗

Facioscapulohumeral muscular dystrophy.Semantic proximity Read ↗

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