Article

A discrete region of the D4Z4 is sufficient to initiate epigenetic silencing

2025-02-23

Abstract excerpt

The DUX4 transcription factor is briefly expressed in the early embryo and is epigenetically repressed in somatic tissues. Loss of epigenetic repression can result in the aberrant expression of DUX4 in skeletal muscle and can cause facioscapulohumeral dystrophy (FSHD). Multiple factors have been identified as necessary to maintain epigenetic silencing of DUX4 in skeletal muscle, but whether specific sequences at...

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Literature Corpus work: 1cc63b03-2903-54ba-af86-44cc76a68436
DOI: 10.1101/2025.02.19.639175

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