Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance.

doi:10.1038/s41467-017-01864-y

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Article

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance.

Nature communications - 30 Nov 2017

Martin Lesley-Ann, Ribas Ricardo, Simigdala Nikiana, Schuster Eugene, Pancholi Sunil, Tenev Tencho, Gellert Pascal, Buluwela Laki, Harrod Alison, Thornhill Allan, Nikitorowicz-Buniak Joanna, Bhamra Amandeep, Turgeon Marc-Olivier, Poulogiannis George, Gao Qiong, Martins Vera, Hills Margaret, Garcia-Murillas Isaac, Fribbens Charlotte, Patani Neill, Li Zheqi, Sikora Matthew J, Turner Nicholas, Zwart Wilbert, Oesterreich Steffi, Carroll Jason, Ali Simak, Dowsett Mitch

Abstract excerpt

Resistance to endocrine therapy remains a major clinical problem in breast cancer. Genetic studies highlight the potential role of estrogen receptor-α (ESR1) mutations, which show increased prevalence in the metastatic, endocrine-resistant setting. No naturally occurring ESR1 mutations have been reported in in vitro models of BC either before or after the acquisition of endocrine resistance making functional...

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PMID: 29192207
DOI: 10.1038/s41467-017-01864-y
PMCID: PMC5709387

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ESR1

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