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Modes of cancer cell invasion and the role of the microenvironment

14 Jul 2015

Abstract excerpt

Metastasis begins with the invasion of tumor cells into the stroma and migration toward the blood stream. Human pathology studies suggest that tumor cells invade collectively as strands, cords and clusters of cells into the stroma, which is dramatically reorganized during cancer progression. Cancer cells in intravital mouse models and in vitro display many 'modes' of migration, from single isolated cells with...

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PMID: 26183445
DOI: 10.1016/j.ceb.2015.06.004

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