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Article

Whom to blame for metastasis, the epithelial-mesenchymal transition or the tumor microenvironment?

Cancer letters - 28 Sept 2016

Pietilä M, Ivaska J, Mani S A

Abstract excerpt

Changes in the tumor microenvironment (TME) can trigger the activation of otherwise non-malignant cells to become highly aggressive and motile. This is evident during initial tumor growth when the poor vascularization in tumors generates hypoxic regions that trigger the latent embryonic program, epithelial-to-mesenchymal transition (EMT), in epithelial carcinoma cells (e-cars) leading to highly motile...

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Identifiers

PMID: 26791236
DOI: 10.1016/j.canlet.2015.12.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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