When overgrowth bumps into cancer: the PTEN-opathies.

Abstract excerpt

PTEN is a dual-specificity phosphatase and well-known tumor suppressor gene. When functioning properly, it works in its canonical pathway to inhibit AKT/mTOR and MAPK signaling, leading to cell death and growth regulation. PTEN mutations cause dysregulation of these pathways, resulting in cellular proliferation and overgrowth. When germline mutations are present as in patients with PTEN Hamartoma Tumor Syndrome...

Topics

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• PTEN gene
• Germ-Line Mutation
• Growth
• Mutation
• Neoplasms
• PI3K/AKT/mTOR signaling in cancer