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Article

Brain overgrowth in disorders of RTK-PI3K-AKT signaling: a mosaic of malformations.

Seminars in perinatology - 1 Feb 2015

Hevner Robert F

Abstract excerpt

Disorders of brain overgrowth are significant causes of intractable epilepsy, intellectual disability, autism, and other complex neurological problems. The pathology of these disorders is sometimes striking and characteristic, as in hemimegalencephaly, but can also be subtle, as in autism. Recent genetic studies have shown that many diverse forms of brain overgrowth are caused by de novo mutations that increase...

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Identifiers

PMID: 25432429
DOI: 10.1053/j.semperi.2014.10.006
PMCID: PMC4268391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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