Article
Plasmablastic lymphoma phenotype is determined by genetic alterations in MYC and PRDM1.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2017
Montes-Moreno Santiago, Martinez-Magunacelaya Nerea, Zecchini-Barrese Tomás, Villambrosía Sonia Gonzalez de, Linares Emma, Ranchal Tamara, Rodriguez-Pinilla María, Batlle Ana, Cereceda-Company Laura, Revert-Arce Jose Bernardo, Almaraz Carmen, Piris Miguel A
Abstract excerpt
Plasmablastic lymphoma is an uncommon aggressive non-Hodgkin B-cell lymphoma type defined as a high-grade large B-cell neoplasm with plasma cell phenotype. Genetic alterations in MYC have been found in a proportion (~60%) of plasmablastic lymphoma cases and lead to MYC-protein overexpression. Here, we performed a genetic and expression profile of 36 plasmablastic lymphoma cases and demonstrate that MYC...
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