Article
NFkappaB regulates plasma apolipoprotein A-I and high density lipoprotein cholesterol through inhibition of peroxisome proliferator-activated receptor alpha.
The Journal of biological chemistry - 3 Oct 2003
Morishima Atsuyuki, Ohkubo Nobutaka, Maeda Nobuji, Miki Tetsuro, Mitsuda Noriaki
Abstract excerpt
The levels of plasma HDL cholesterol and apoA-I in NFkappaB p50 subunit-deficient mice were significantly higher than those in wild-type mice under regular and high fat diets, without any significant difference in the level of total cholesterol. To examine the role of NFkappaBin lipid metabolism, we studied its effect on the regulation of apoA-I secretion from human hepatoma HepG2 cells....
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