Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in DNA repair genes as risk factors for spina bifida and orofacial clefts.

American journal of medical genetics. Part A - 15 Jun 2005

Olshan Andrew F, Shaw G M, Millikan R C, Laurent C, Finnell R H

Abstract excerpt

Repairing DNA damage is critical during embryogenesis because development involves sensitive periods of cell proliferation, and abnormal cell growth or death can result in malformations. Knockout mouse experiments have demonstrated that disruption of DNA repair genes results in embryolethality and structural defects. Studies using mid-organogenesis rat embryos showed that DNA repair genes were variably expressed....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Glycosylases
Share to Cleft Lip
Share to Cleft Palate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Share to Neonatal Screening

Share to Spinal Dysraphism

Share to X-ray Repair Cross Complementing Protein 1

Share to Xeroderma Pigmentosum Group D Protein

Source

Identifiers

PMID: 15887293
DOI: 10.1002/ajmg.a.30713

Genes

XRCC3
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in DNA repair genes as risk factors for spina bifida and orofacial clefts.PMID 15887293Read ↗

Loss of RAD9B impairs early neural development and contributes to the risk for human spina bifida.Semantic proximity Read ↗

The genetics and epigenetics of orofacial clefts.Semantic proximity Read ↗

Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida.Semantic proximity Read ↗

The genetic factors contributing to the risk of cleft lip-cleft palate and their clinical utility.Semantic proximity Read ↗

Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinningsSemantic proximity Read ↗

Epidemiologic and genetic aspects of spina bifida and other neural tube defects.Semantic proximity Read ↗

Rare deleterious variants in GRHL3 are associated with human spina bifida.Semantic proximity Read ↗

Genetics of nonsyndromic oral clefts revisited.Semantic proximity Read ↗

Heme oxygenase-1 promoter polymorphisms and risk of spina bifida.Semantic proximity Read ↗

Genes encoding critical transcriptional activators for murine neural tube development and human spina bifida: a case-control study.Semantic proximity Read ↗

Review on genetic variants and maternal smoking in the etiology of oral clefts and other birth defects.Semantic proximity Read ↗

Maternal arsenic exposure modifies associations between arsenic, folate and arsenic metabolism gene variants, and spina bifida risk: A case‒control study in Bangladesh.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.