Detection of novel and potentially actionable anaplastic lymphoma kinase (ALK) rearrangement in colorectal adenocarcinoma by immunohistochemistry screening.

doi:10.18632/oncotarget.4462

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Article

Detection of novel and potentially actionable anaplastic lymphoma kinase (ALK) rearrangement in colorectal adenocarcinoma by immunohistochemistry screening.

Oncotarget - 15 Sept 2015

Lee Jeeyun, Kim Hee Cheol, Hong Jung Yong, Wang Kai, Kim Sun Young, Jang Jiryeon, Kim Seung Tae, Park Joon Oh, Lim Ho Yeong, Kang Won Ki, Park Young Suk, Lee Jiyun, Lee Woo Yong, Park Yoon Ah, Huh Jung Wook, Yun Seong Hyeon, Do In-Gu, Kim Seok Hyung, Balasubramanian Sohail, Stephens Philip J, Ross Jeffrey S, Li Gang Gary, Hornby Zachary, Ali Siraj M, Miller Vincent A, Kim Kyoung-Mee, Ou Sai-Hong Ignatius

Abstract excerpt

PURPOSE: Anaplastic lymphoma kinase (ALK) rearrangement has been detected in colorectal carcinoma (CRC) using advanced molecular diagnostics tests including exon scanning, fluorescence in situ hybridization (FISH), and next generation sequencing (NGS). We investigated if immunohistochemistry (IHC) can be used to detect ALK rearrangement in gastrointestinal malignancies. EXPERIMENTAL DESIGNS: Tissue microarrays...

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Identifiers

PMID: 26172300
DOI: 10.18632/oncotarget.4462
PMCID: PMC4695188

Genes

ALK
EML4
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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