Article
A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy.
Current protein & peptide science - 1 Jan 2024
Mesquita Felipe Pantoja, Lima Luina Benevides, da Silva Emerson Lucena, Souza Pedro Filho Noronha, de Moraes Maria Elisabete Amaral, Burbano Rommel Mario Rodrigues, Montenegro Raquel Carvalho
Abstract excerpt
Gastric adenocarcinoma is a complex disease with diverse genetic modifications, including Anaplastic Lymphoma Kinase (ALK) gene changes. The ALK gene is located on chromosome 2p23 and encodes a receptor tyrosine kinase that plays a crucial role in embryonic development and cellular differentiation. ALK alterations can result from gene fusion, mutation, amplification, or overexpression in gastric adenocarcinoma....
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