Article
Colorectal Adenocarcinomas Harboring ALK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 12 Cases and Review of the Literature.
The American journal of surgical pathology - 1 Sept 2020
Lasota Jerzy, Chłopek Małgorzata, Wasąg Bartosz, Kowalik Artur, Christiansen Jason, Lamoureux Jennifer, Kuźniacka Alina, Felisiak-Gołąbek Anna, Liu Yalan, Reyes Tiffany Ashley R, Saha Rishabh, Agaimy Abbas, Behenska Kristyna, Biernat Wojciech, Cattaneo Laura, Centonze Giovanni, Daum Ondrej, Daumova Magdalena, Domagała Paweł, Dziuba Ireneusz, Geppert Carol E, Góźdź Stanisław, Nasierowska-Guttmejer Anna, Hałoń Agnieszka, Hartmann Arndt, Inaguma Shingo, Iżycka-Świeszewska Ewa, Kaczorowski Maciej, Kołos Małgorzata, Kopczyński Janusz, Michal Michal, Milione Massimo, Okoń Krzysztof, Pęksa Rafał, Pyzlak Michał, Ryś Janusz, Waloszczyk Piotr, Wejman Jaroslaw, Miettinen Markku
Abstract excerpt
This study determined the frequency and the clinicopathologic and genetic features of colorectal carcinomas driven by oncogenic fusions of the anaplastic lymphoma kinase gene (ALK). Of the 8150 screened tumors, 12 (0.15%) were immunohistochemically ALK-positive with D5F3 antibody. These cancers harbored CAD-ALK (n=1), DIAPH2-ALK (n=2), EML4-ALK (n=2), LOC101929227-ALK (n=1), SLMAP-ALK (n=1), SPTBN1-ALK (n=4), and...
Topics
Join the communities discussing this publication.