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Article

Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer

1 Dec 2015

Abstract excerpt

BACKGROUND: Activated anaplastic lymphoma kinase (ALK) gene fusions are recurrent events in a small fraction of colorectal cancers (CRCs), although these events have not yet been exploited as in other malignancies. METHODS: We detected ALK protein expression by immunohistochemistry and gene rearrangements by fluorescence in situ hybridisation in the ALKA-372-001 phase I study of the pan-Trk, ROS1, and ALK...

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PMID: 26633560
DOI: 10.1038/bjc.2015.401

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