Article
Increased B and T Cell Responses in M. bovis Bacille Calmette-Guérin Vaccinated Pigs Co-Immunized with Plasmid DNA Encoding a Prototype Tuberculosis Antigen.
PloS one - 1 Jan 2015
Bruffaerts Nicolas, Pedersen Lasse E, Vandermeulen Gaëlle, Préat Véronique, Stockhofe-Zurwieden Norbert, Huygen Kris, Romano Marta
Abstract excerpt
The only tuberculosis vaccine currently available, bacille Calmette-Guérin (BCG) is a poor inducer of CD8(+) T cells, which are particularly important for the control of latent tuberculosis and protection against reactivation. As the induction of strong CD8(+) T cell responses is a hallmark of DNA vaccines, a combination of BCG with plasmid DNA encoding a prototype TB antigen (Ag85A) was tested. As an alternative...
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