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Article

Pre-clinical development of BCG.HIVA(CAT), an antibiotic-free selection strain, for HIV-TB pediatric vaccine vectored by lysine auxotroph of BCG.

PloS one - 1 Jan 2012

Saubi Narcís, Mbewe-Mvula Alice, Gea-Mallorqui Ester, Rosario Maximillian, Gatell Josep Maria, Hanke Tomáš, Joseph Joan

Abstract excerpt

In the past, we proposed to develop a heterologous recombinant BCG prime-recombinant modified vaccinia virus Ankara (MVA) boost dual pediatric vaccine platform against transmission of breast milk HIV-1 and Mycobacterium tuberculosis (Mtb). In this study, we assembled an E. coli-mycobacterial shuttle plasmid pJH222.HIVA(CAT) expressing HIV-1 clade A immunogen HIVA. This shuttle vector employs an antibiotic...

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Source

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Identifiers

PMID: 22927933
DOI: 10.1371/journal.pone.0042559
PMCID: PMC3424164

Genes

CAT
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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