Article
Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations.
European journal of immunology - 1 Nov 2007
Beveridge Natalie E R, Price David A, Casazza Joseph P, Pathan Ansar A, Sander Clare R, Asher Tedi E, Ambrozak David R, Precopio Melissa L, Scheinberg Phillip, Alder Nicola C, Roederer Mario, Koup Richard A, Douek Daniel C, Hill Adrian V S, McShane Helen
Abstract excerpt
In the search for effective vaccines against intracellular pathogens such as HIV, tuberculosis and malaria, recombinant viral vectors are increasingly being used to boost previously primed T cell responses. Published data have shown prime-boost vaccination with BCG-MVA85A (modified vaccinia virus Ankara expressing antigen 85A) to be highly immunogenic in humans as measured by ex vivo IFN-gamma ELISPOT. Here, we...
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