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DNA Vaccine Constructs Expressing Mycobacterium tuberculosis-Specific Genes Induce Immune Responses

20 Jul 2010

Abstract excerpt

RD1 PE35, PPE68, EsxA, EsxB and RD9 EsxV genes are present in Mycobacterium tuberculosis genome but deleted in Mycobacterium bovis BCG. The aim of this study was to clone these genes into DNA vaccine vectors capable of expressing them in eukaryotic cells as fusion proteins, fused with immunostimulatory signal peptides of human interleukin-2 (hIL-2) and tissue plasminogen activator (tPA), and evaluate the...

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PMID: 21039735
DOI: 10.1111/j.1365-3083.2010.02452.x

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