Vaccination with Plasmid DNA Encoding Mycobacterial Antigen 85A Stimulates a CD4⁺and CD8⁺T-Cell Epitopic Repertoire Broader than That Stimulated by<i>Mycobacterium tuberculosis</i>H37Rv Infection

Abstract excerpt

Vaccination of mice with plasmid DNA carrying the gene for the major secreted mycobacterial antigen 85A (Ag85A) from Mycobacterium tuberculosis is a powerful technique for generating robust specific Thl helper T-cell responses, CD8+-mediated cytotoxicity, and protection against M. tuberculosis challenge (K. Huygen et al., Nat. Med. 2:893-898, 1996). We have now analyzed in more detail the antigen-specific immune...

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