Article
The interplay between DNA methylation and sequence divergence in recent human evolution.
Nucleic acids research - 30 Sept 2015
Hernando-Herraez Irene, Heyn Holger, Fernandez-Callejo Marcos, Vidal Enrique, Fernandez-Bellon Hugo, Prado-Martinez Javier, Sharp Andrew J, Esteller Manel, Marques-Bonet Tomas
Abstract excerpt
Despite the increasing knowledge about DNA methylation, the understanding of human epigenome evolution is in its infancy. Using whole genome bisulfite sequencing we identified hundreds of differentially methylated regions (DMRs) in humans compared to non-human primates and estimated that ∼25% of these regions were detectable throughout several human tissues. Human DMRs were enriched for specific histone...
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