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Article

The senescent microenvironment promotes the emergence of heterogeneous cancer stem-like cells

13 Jul 2015

Abstract excerpt

There is a well-established association between aging and the onset of metastasis. Although the mechanisms through which age impinges upon the malignant phenotype remain uncharacterized, the role of a senescent microenvironment has been emphasized. We reported previously that human epithelial cells that undergo telomere-driven chromosome instability (T-CIN) display global microRNA (miR) deregulation and develop...

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PMID: 26168819
DOI: 10.1093/carcin/bgv101

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